The team solves crimes committed by and against mutants, often dealing with the fallout of the House of M "Decimation" where most mutants lost their powers.
A central early antagonist is Singularity Investigations , a massive, corrupt firm led by the ancient "changeling" Damian Tryp . X-Factor v3 (X-Factor Investigations) (2004-201...
Following the Madrox miniseries, Jamie Madrox uses wealth from a game show to fund a private investigation firm. The team solves crimes committed by and against