(Machta et al., 2013): Explains why complicated microscopic processes often result in simple macroscopic behavior. Core Concepts of "Sloppy" Research
In scientific literature, a "sloppy" model refers to a complex multiparameter system where model behavior is highly sensitive to only a few "stiff" parameter combinations, while the majority of "sloppy" directions in parameter space have almost no effect on model predictions. sloppy
(Gutenkunst et al., 2007): Demonstrates that sloppiness is a universal feature in systems biology, suggesting that modelers should focus on predictions rather than exact parameter values. (Machta et al
: A few parameter combinations ("stiff") tightly constrain model behavior, while others ("sloppy") can vary by orders of magnitude without changing the output. (Machta et al.