: The proposed SKN space, when used with a Random Forest classifier, achieved a high F-score of 0.953 , outperforming standard color spaces like RGB, HSV, and YCbCr.

: RARs are the primary targets for topical retinoids (like tretinoin or tazarotene) used to treat acne, photoaging, and skin cancer .

: Researchers used a Genetic Algorithm to find the optimal combination of color components and Principal Component Analysis (PCA) to reduce complexity.

: Research shows that these receptors regulate cell differentiation and the skin's protective barrier function.