The season begins with the remaining Runaways—Nico, Alex, Molly, and Xavin—desperately searching for , who were captured or separated at the end of Season 2.

Karolina, Chase, and Janet Stein are held in a virtual reality "simulation" that mimics their ideal lives.

The Gibborim Magistrate and his family have possessed various Pride parents, including Victor Stein and Stacey Yorkes, to use them as hosts while they plot an invasion.