The story picks up after the events of the first film. Despite the destruction of the original giant crocodile, another massive, mutated reptile hatches from a surviving egg in the Caribbean swamps of Santo Domingo.

: Feisty New York reporter Liza Post (Debra Karr) travels to the area to investigate Mr. Baxter, an unscrupulous property developer planning to build a swanky resort on land still contaminated by illegal toxic waste dumping.

: As Baxter tries to silence Liza, the new crocodile begins terrorizing the locals, claiming victims ranging from corrupt boatmen to an entire boat full of school children and a nun.