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Glycogen supports glycolytic plasticity in neurons - PMC - NIH

This paper explores the role of glycogen as a metabolic fuel source within neurons, specifically focusing on Glycogen-Dependent Glycolytic Plasticity (GDGP). Recent studies using sensors like HYlight in models such as Caenorhabditis elegans have identified that neurons can utilize glycogen to regulate glycolytic states during periods of high activity or transient hypoxia. This study highlights the essential role of PYGL-1, an ortholog of human glycogen phosphorylase, in sustaining this plasticity. Introduction

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Traditionally, neurons were thought to rely primarily on blood-glucose-derived glucose, with astrocytes managing glycogen storage. However, evidence now indicates that neurons can engage in their own glycogen-dependent glycolytic plasticity (GDGP) to meet sudden metabolic demands. This paper investigates how GDGP operates, specifically in mitigating the effects of mitochondrial dysfunction. Findings on GDGP Mechanisms Glycogen supports glycolytic plasticity in neurons - PMC

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-related research (such as cell-level studies or related data). Introduction To make this paper more accurate for

Neurons employ both glycogen-dependent (GDGP) and glycogen-independent pathways to maintain glycolytic plasticity. Conclusion