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While splenectomy was previously the gold standard, bone marrow biopsy (showing intrasinusoidal infiltration) is now a primary diagnostic tool. Genetics: Deletion of Download Lymphomes splГ©niques pdf
Splenic lymphomas remain a diagnostic challenge due to their rarity and overlap with other indolent B-cell neoplasms. Advances in molecular profiling and the success of anti-CD20 monoclonal antibodies have shifted the treatment paradigm away from invasive surgery toward targeted medical therapy. Suggested Resources for PDF Download For patient-oriented and clinical summaries
The World Health Organization (WHO) and the International Consensus Classification (ICC) categorize these into three main entities: Advances in molecular profiling and the success of
Now reserved for refractory cases or emergency management of splenic rupture.
Currently considered the first-line standard of care, offering high response rates with low toxicity.
Treatment is indicated only for symptomatic patients (progressive cytopenia or painful splenomegaly).