The identifier primarily refers to a significant scientific study published in Cell Reports titled "Chronic stress primes innate immune responses in mice and humans," which explores how long-term psychological stress impacts the immune system at a cellular level. Overview of Study 109595
: It also refers to a recent eLife reviewed preprint (109595) that uses fruit flies to model RVCL-S , a rare genetic disease affecting blood vessels in the brain and retina. 109595
: While this "primed" state might seem helpful for fighting infections, it often leads to pathological inflammation , increasing the risk for cardiovascular diseases, autoimmune disorders, and severe inflammatory responses (such as those seen in COVID-19). Critical Review and Assessment The identifier primarily refers to a significant scientific
The methodology and findings of this study have been widely cited in the medical community for bridging the gap between psychology and physical pathology. Critical Review and Assessment The methodology and findings
: Experts note that while the "priming" is clearly observed, the exact duration of these epigenetic changes remains an open question for future research.
: In both mice and humans, chronic stress was found to reprogram myeloid progenitor cells in the bone marrow. This leads to an increased production of monocytes that are more reactive to future threats.